4.4· 209 reviews

Bromelain 500mg

A high-potency pineapple-derived enzyme supplement formulated to support the body's natural protein digestion and everyday joint comfort.

  • Vegan
  • Non-GMO
  • Soy-Free
  • Gluten-Free
  • Made in USA

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Supplement Facts

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 120

Nutrient Amount Per Serving % DV*
Bromelain (2,400 Gelatin Digesting Units (GDU)/gram) (from Pineapple) 500mg *

* Percent Daily Values are based on a 2,000 calorie diet.

** Daily Value not established.

Other Ingredients: Methylcellulose Capsule.

How to Use
Take 1 capsule twice daily, with meals for digestive support, or between meals for systemic enzyme support.
Research

The studies below reference peer-reviewed research on the key active ingredients in this product. These are ingredient-level studies.

Bromelain (2,400 GDU/gram) (from Pineapple)

  • Castell et al., 1997 · American Journal of Physiology

    Double-blind RCT; n=19 healthy men; multi-dose phase over 48 hours

    Participants who received oral bromelain showed measurable intact enzyme in plasma with a half-life of 6–9 hours, demonstrating that bromelain is absorbed across the gastrointestinal epithelium and retains enzymatic activity in circulation following oral dosing.

  • Pereira et al., 2023 · Clinical Nutrition ESPEN

    Systematic review of RCTs; 7 eligible trials included; 1–16 week durations; dosages 99.9–1,200 mg/day

    A systematic review of randomized controlled trials found that participants who received bromelain supplementation showed reductions in inflammatory markers including IL-6, TNF-α, and CRP in most included studies, with gastrointestinal adverse effects reported as well-tolerated across the reviewed trials.

  • Delgarm et al., 2025 · Scientific Reports

    Randomized, triple-blind, placebo-controlled trial; n=70; 8 weeks; participants with mild-to-moderate ulcerative colitis

    Participants with mild-to-moderate ulcerative colitis who received 400mg/day of bromelain showed significantly larger reductions in disease activity scores compared to those who received placebo (P < 0.001); quality-of-life measures did not differ significantly between groups in this population.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

How it works

Every ingredient, chosen with intention.

Here's what's in this bottle - and why each ingredient earned its place in the formula.

  1. Bromelain

    Bromelain from pineapple stem (Ananas comosus)

    A proteolytic enzyme complex derived from pineapple stem that helps break down proteins into smaller peptides and amino acids. Measured in Gelatin Digesting Units (GDU), this formula provides 2,400 GDU per gram, indicating high enzymatic activity per milligram of extract.

    Why we chose it

    At 500mg, a full therapeutic-range dose, this is one of the more concentrated bromelain supplements available. The activity rating of 2,400 GDU/g is included on the label because milligram weight alone doesn't tell you how active the enzyme is: two 500mg bromelain supplements can have very different enzymatic potency depending on how the extract was processed.

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Questions, answered

What customers often ask.

What does 2,400 GDU per gram actually measure?
GDU stands for Gelatin Digesting Units, a standardized measure of how much enzyme activity is present, not just how much powder is in the capsule. 2,400 GDU/gram is a high-potency rating. It means each 500mg capsule delivers meaningful enzymatic activity, not just inert bromelain residue.
Should I take this with meals or on an empty stomach?
It depends on your goal. For digestive support, helping your body break down proteins in a meal, take it with food. For anti-inflammatory or joint support, some people prefer taking it between meals on an empty stomach, which allows more absorption into circulation rather than acting on food in the gut.
How is this different from the papaya enzyme tablets?
The papaya enzyme tablets combine papain, bromelain at 10mg, and a plant enzyme blend to cover broad digestive support. This product is a high-dose standalone: 500mg of bromelain specifically, for those who want a larger amount of this enzyme, whether for joint comfort, recovery, or digestive use, without the blended formula.
Can I take this if I'm allergic to pineapple?
Bromelain is derived from pineapple stem. If you have a documented pineapple allergy, consult your healthcare provider before taking this supplement. Cross-reactivity between pineapple and bromelain is possible, though allergy responses to the isolated enzyme differ from responses to the whole fruit.
Does bromelain interact with any medications?
Bromelain may interact with blood thinners and certain antibiotics. Please consult your healthcare provider before taking this supplement if you are on anticoagulants, antiplatelet medications, or antibiotics. The research is not conclusive, but professional guidance is warranted when combining supplements with medications.
How long until I notice a benefit for joint or muscle comfort?
Studies on bromelain's anti-inflammatory markers look at one to eight week timeframes with consistent daily use. For digestive support, the effect is per-meal, it works when it's present with food. For joint and muscle comfort, give it two to four weeks of daily use before assessing.

What customers say

Results, backed by reviews.