4.4· 213 reviews

Bromelain 500mg

A high-potency pineapple-derived enzyme supplement formulated to support the body's natural protein digestion and everyday joint comfort.

  • Vegan
  • Non-GMO
  • Soy-Free
  • Gluten-Free
  • Made in USA

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Supplement Facts

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 120

Nutrient Amount Per Serving % DV*
Bromelain (2,400 Gelatin Digesting Units (GDU)/gram) (from Pineapple) 500mg *

* Percent Daily Values are based on a 2,000 calorie diet.

** Daily Value not established.

Other Ingredients: Methylcellulose Capsule.

How to Use
Take 1 capsule twice daily, with meals for digestive support, or between meals for systemic enzyme support.
Research

The studies below reference peer-reviewed research on the key active ingredients in this product. These are ingredient-level studies.

Bromelain (2,400 GDU/gram) (from Pineapple)

  • Castell et al., 1997 · American Journal of Physiology

    Double-blind RCT; n=19 healthy men; multi-dose phase over 48 hours

    Participants who received oral bromelain showed measurable intact enzyme in plasma with a half-life of 6–9 hours, demonstrating that bromelain is absorbed across the gastrointestinal epithelium and retains enzymatic activity in circulation following oral dosing.

  • Pereira et al., 2023 · Clinical Nutrition ESPEN

    Systematic review of RCTs; 7 eligible trials included; 1–16 week durations; dosages 99.9–1,200 mg/day

    A systematic review of randomized controlled trials found that participants who received bromelain supplementation showed reductions in inflammatory markers including IL-6, TNF-α, and CRP in most included studies, with gastrointestinal adverse effects reported as well-tolerated across the reviewed trials.

  • Delgarm et al., 2025 · Scientific Reports

    Randomized, triple-blind, placebo-controlled trial; n=70; 8 weeks; participants with mild-to-moderate ulcerative colitis

    Participants with mild-to-moderate ulcerative colitis who received 400mg/day of bromelain showed significantly larger reductions in disease activity scores compared to those who received placebo (P < 0.001); quality-of-life measures did not differ significantly between groups in this population.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

How it works

Every ingredient, chosen with intention.

Here's what's in this bottle - and why each ingredient earned its place in the formula.

  1. Bromelain

    Bromelain from pineapple stem (Ananas comosus)

    A proteolytic enzyme complex derived from pineapple stem that helps break down proteins into smaller peptides and amino acids. Measured in Gelatin Digesting Units (GDU), this formula provides 2,400 GDU per gram, indicating high enzymatic activity per milligram of extract.

    Why we chose it

    At 500mg, a full therapeutic-range dose, this is one of the more concentrated bromelain supplements available. The activity rating of 2,400 GDU/g is included on the label because milligram weight alone doesn't tell you how active the enzyme is: two 500mg bromelain supplements can have very different enzymatic potency depending on how the extract was processed.

Pairs well with

Complete your routine.

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Vegan Daily Cleanse Papaya Enzymes

A plant-sourced enzyme blend that helps your body break down proteins, fats, and carbs from everyday meals.

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DGL Licorice Chewables

A chewable plant-based licorice root extract with glycyrrhizin removed, formulated to support stomach comfort and everyday digestive ease.

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Vegan Prebiotic Fiber Gummies

A daily plant-based fiber gummy with inulin from chicory root, formulated to support the growth of beneficial bacteria in the gut.

Questions, answered

What customers often ask.

What does 2,400 GDU per gram actually measure?
GDU stands for Gelatin Digesting Units, a standardized measure of how much enzyme activity is present, not just how much powder is in the capsule. 2,400 GDU/gram is a high-potency rating. It means each 500mg capsule delivers meaningful enzymatic activity, not just inert bromelain residue.
Should I take this with meals or on an empty stomach?
It depends on your goal. For digestive support, helping your body break down proteins in a meal, take it with food. For anti-inflammatory or joint support, some people prefer taking it between meals on an empty stomach, which allows more absorption into circulation rather than acting on food in the gut.
How is this different from the papaya enzyme tablets?
The papaya enzyme tablets combine papain, bromelain at 10mg, and a plant enzyme blend to cover broad digestive support. This product is a high-dose standalone: 500mg of bromelain specifically, for those who want a larger amount of this enzyme, whether for joint comfort, recovery, or digestive use, without the blended formula.
Can I take this if I'm allergic to pineapple?
Bromelain is derived from pineapple stem. If you have a documented pineapple allergy, consult your healthcare provider before taking this supplement. Cross-reactivity between pineapple and bromelain is possible, though allergy responses to the isolated enzyme differ from responses to the whole fruit.
Does bromelain interact with any medications?
Bromelain may interact with blood thinners and certain antibiotics. Please consult your healthcare provider before taking this supplement if you are on anticoagulants, antiplatelet medications, or antibiotics. The research is not conclusive, but professional guidance is warranted when combining supplements with medications.
How long until I notice a benefit for joint or muscle comfort?
Studies on bromelain's anti-inflammatory markers look at one to eight week timeframes with consistent daily use. For digestive support, the effect is per-meal, it works when it's present with food. For joint and muscle comfort, give it two to four weeks of daily use before assessing.

What customers say

Results, backed by reviews.

  • 5 stars: 129 (61%)
  • 4 stars: 55 (26%)
  • 3 stars: 19 (9%)
  • 2 stars: 10 (5%)
  • 1 star: 0 (0%)
C
Caleb F.
After a big meal

I bought this out of curiosity after a few very heavy restaurant meals. Taking it after dinner has felt comfortable, and I like that it is pineapple-derived.

A
ARTHUR V.
No clear difference

Three weeks in. No clear difference after heavy meals.

s
sandy_11
Heavy meals

I bought this because I was curious about a pineapple-derived enzyme and tend to overdo it at family dinners. I do not take it every day. It is more of a 'we ordered too much' bottle for me. After a few especially heavy meals, I felt less weighed down afterward and did not have that sluggish feeling for the rest of the evening. The capsules have no noticeable taste and have been easy on my stomach. Four stars only because the bottle is smaller than I pictured, but the product itself has been a useful addition to the cabinet.

J
Jason P.
Helpful after dinner

I picked this because I was curious about a pineapple-derived enzyme and tend to feel extra full after heavier dinners. I use it with the meal instead of waiting until I am uncomfortable. It has been a nice addition on pasta nights and after takeout. Nothing flashy, but I notice I am more comfortable afterward and that is exactly why I bought it.

R
Rachel
Not sure yet

Not sure yet. no bad reaction, just not wowed

m
monica84
Joint comfort bonus

Started for digestion after big dinners but noticed my knees felt a bit less cranky after long walks. Could be timing, idk, but I reordered.

K
Kevin A.
Heavy meals feel easier

I bought this because pineapple enzymes kept coming up in digestion forums. I take it after bigger meals and notice less post-meal bloat. Not a magic trick, just useful.

s
sunrise88
Clean pineapple enzyme

Single-ingredient enzyme supplement with clean excipients. No fillers, no unnecessary additives. Effective and simple.

L
LINDA P.
Good for protein digestion too

Taking with high-protein meals and digestion is smoother. Bromelain breaks down protein. Two benefits in one supplement.

R
R. Kim
Joints are better

Joints are better. 500mg dose works.

t
tbaker_
Sinuses and joints together

Was taking this for joints but the sinus benefit was almost immediate. Within 2 weeks both my joints and sinuses felt better. Bromelain addresses inflammation wherever it is.

G
GINA M.
Natural anti-inflammatory

Didn't want to take NSAIDs long-term. Bromelain was my rheumatologist-approved alternative. Three months in and my inflammation markers improved at my last bloodwork.

D
DIANE F.
Post-dental work

My dentist said bromelain was safe to take after a procedure for swelling management. It worked. Jaw swelling went down faster than previous procedures.

p
pk_22
Joint pain is noticeably less

I have early arthritis in my knees. Started bromelain on my naturopath's recommendation. Six weeks in and my daily knee discomfort is noticeably less. Still have bad days but the baseline has improved.

A
Ashley
Changed my post-run recovery

Before bromelain: 2-3 days of significant soreness after long runs. After bromelain: 1 day of mild soreness. That difference is significant when you're training 5 days a week and need to be able to run again quickly. I've also noticed my joints feel more comfortable during long runs, not just after. This is now a permanent part of my training supplement stack.

z
zach_t
Reduced NSAID use meaningfully

Used to take ibuprofen several times a week for joint pain. Since starting bromelain I barely take NSAIDs. My gastroenterologist is glad — NSAIDs are hard on the gut.

k
kpatel88
Sprained ankle, remarkable recovery

I twisted my ankle badly in February playing basketball. Previous ankle injuries have taken me 6-8 weeks to recover from. Started bromelain immediately this time — the day it happened.

The swelling was less dramatic than previous injuries from day one. My physical therapist commented at my second appointment that the tissue response looked unusually good for a grade 2 sprain. I was back to running in 4 weeks, which is faster than any previous ankle injury.

I don't know how much of that is the bromelain specifically vs other factors, but it's now the first thing I reach for when I have any acute inflammation. The evidence base is solid and my personal experience confirms it.

J
Jennifer M.
Good dose, real results

Did research before buying — many bromelain supplements have doses too low to do anything. 500mg is in the therapeutic range. My joints confirm it.

D
David C.
Shoulder inflammation addressed

Chronic shoulder inflammation from years of swimming. Bromelain plus physical therapy has been more effective than either alone. Shoulder feels the best it has in three years.

B
Brian
Sinuses cleared

Sinuses cleared within 3 weeks. Wasn't even expecting that.

L
Lisa
Post-workout recovery

I run marathons and the inflammation after long runs was brutal. Started bromelain and recovery is measurably faster. Less swelling, less soreness, back to training sooner.

J
J. Williams
Works on empty stomach

Taking between meals as recommended for anti-inflammatory effect. On a full stomach it's a digestive enzyme, between meals it's anti-inflammatory. Taking it right makes a difference.

R
ROBERT H.
Helped with back inflammation

Chronic back pain from sitting at a desk all day. Bromelain takes the edge off the inflammation. Not a cure but meaningful daily improvement.

C
Chris
500mg dose is serious

The dose in this supplement is a real therapeutic dose, not a token amount. That matters. My inflammation has responded to it noticeably and I've tried weaker formulas that didn't work.

J
JAMES W.
Good for aging athletes

I'm 52 and running is getting harder on my joints. Bromelain is part of my anti-inflammation toolkit. Recovery between runs is noticeably faster.

D
David
Consistent use pays off

Been taking daily for 8 weeks. Joint comfort steadily improved over that time. Not overnight but consistent and real.

M
Margaret
Arthritis in my hands

Early osteoarthritis in my hands. Bromelain has been one of the more effective natural interventions. Hands are less stiff in the mornings since starting 2 months ago.

N
N. Reyes
Swelling resolved faster

Swelling from ankle injury resolved significantly faster than expected.

a
active_recovery
Fantastic results

Take it between meals so it absorbs systemically rather than acting only digestively. Joint inflammation from my decade-old soccer injury reduced by about 60%. I track pain on a scale daily and went from averaging 6-7 to averaging 2-3 over 3 months. My sports medicine doctor reviewed the approach and said it's evidence-based. I am a convert

E
Emma S.
Must have

my dentist recommended this. worked perfectly after extraction

t
triathlete_support
Recommended

I run competitively in the masters division, which means my body is perpetually in some state of inflammation from high mileage. Tried many recovery supplements over the years with mixed results. Bromelain was recommended by a fellow runner who credited it with extending her competitive career. Started taking it 3 months ago. Honest assessment: it helps but is not revolutionary for me. Soreness is somewhat reduced. Recovery between hard sessions maybe 20-25% faster. Not the dramatic transformation some describe but a consistent moderate benefit. I think some people have a stronger enzyme response than others. For me it is a reliable workhorse that does what it says at a moderate level. I keep buying because the moderate consistent benefit adds up over a training season. Four stars for a product that delivers without drama or miracles

f
foot_injury_fi
Nice product

Competitive masters weightlifter. Recovery between heavy training days is the limiting factor at my age. DOMS reduced about 25-30% and I return to heavy training about half a day sooner. Not revolutionary but consistent. Over a full training season that adds up to meaningful extra volume and better quality sessions