Participants with functional dyspepsia who received a deglycyrrhizinated licorice preparation (GutGard®) showed statistically significant reductions in dyspepsia symptom scores compared to those who received placebo (P < 0.05); DGL preparations have had the glycyrrhizin component removed to reduce risks associated with high-dose whole-licorice intake.
Participants with self-reported unsatisfactory sleep who received glycine supplementation (3g) before bedtime showed statistically significant improvements in subjective sleep quality, daytime sleepiness, and fatigue scores compared to those who received placebo; small sample size limits generalizability of these findings.
Participants whose sleep was experimentally restricted who received glycine (3g/day) showed statistically significant reductions in daytime sleepiness and psychomotor vigilance test fatigue compared to those who received placebo; results were specific to the sleep-restricted condition and the dose studied (3g) exceeds the amount in this product.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
DGL Licorice$17.84
How it works
Every ingredient, chosen with intention.
Here's what's in this bottle - and why each ingredient earned its place in the formula.
A concentrated extract of licorice root processed to remove glycyrrhizin, the compound responsible for licorice root's potential effects on blood pressure and hormone balance at sustained high doses, while retaining the root's other active compounds.
Why we chose it
760mg per serving is a meaningful dose. The deglycyrrhizination step removes the one limiting component of whole licorice root, making a high, consistent daily amount practical without the constraints that come with glycyrrhizin accumulation over time.
L-Glycine
a conditionally essential amino acid
The simplest amino acid, used as a building block for proteins including collagen, and as a precursor to compounds the body produces. Included here as a functional co-ingredient alongside the licorice extract.
Why we chose it
Glycine is one of the few amino acids with established mucosal-relevant properties in cell research, pairing logically with a formula designed for digestive support.
A daily plant-based fiber gummy with inulin from chicory root, formulated to support the growth of beneficial bacteria in the gut.
Questions, answered
What customers often ask.
What does DGL mean and why does it matter?
DGL stands for deglycyrrhizinated licorice, licorice root that has had glycyrrhizin removed through a water extraction process. Glycyrrhizin at high doses can affect blood pressure and electrolyte balance. Removing it makes a 760mg daily dose practical for ongoing digestive support without those concerns.
Should I take these capsules before or after eating?
Most people take DGL before meals for proactive stomach comfort. If you experience occasional post-meal discomfort, taking it shortly after eating is also common. There's flexibility, the goal is to have it present in the GI tract when you need it most.
How long before I notice a difference?
A randomized controlled trial on a DGL preparation showed statistically significant reductions in dyspepsia symptom scores at 30 days compared to placebo. Daily consistent use tends to show the clearest results, sporadic use is less studied. Individual timelines vary.
Is this safe if I take blood pressure medication?
Please consult your healthcare provider before taking DGL if you're on blood pressure medication, diuretics, or any cardiac medications. While the glycyrrhizin has been removed, your healthcare provider is best positioned to advise on supplement interactions specific to your medication regimen.
How is this different from the DGL Licorice Chewables?
This capsule formula delivers 760mg of DGL extract per serving, almost double the 400mg in the chewable version. If you prefer swallowing a capsule and want a higher per-serving dose, this is the option. The chewable version activates pre-digestively but at a lower dose per serving.
What is L-Glycine doing in this formula?
Glycine is an amino acid with naturally occurring properties relevant to digestive tissue. It's included as a functional co-ingredient alongside the licorice extract, not as the primary active ingredient, but as a complement to DGL's support for the stomach's mucosal environment.
